Home / Resources / Blog / Vicodin and Its Potential Link to Increased Risk of Mental Health Disorders

Vicodin and Its Potential Link to Increased Risk of Mental Health Disorders


, ,

Medically Reviewed by Dr. Mohammed Saeed, MD.

Vicodin, a prescription medication commonly prescribed for pain management, has gained notoriety for its pain-relieving properties. However, Vicodin has a dark side. Although Vicodin can effectively ease physical discomfort, there is a growing concern that its use might contribute to an increased risk of certain mental health disorders.

What Is Vicodin & How Does It Work?

Vicodin is a combination medication that contains two active ingredients: hydrocodone and acetaminophen. Hydrocodone is an opioid pain reliever. Acetaminophen also helps relieve pain but acts as a fever reducer as well. Generally, doctors prescribe Vicodin to manage moderate to severe pain, such as post-surgery pain.

Vicodin works by binding to opioid receptors in the brain and spinal cord. When this happens, the medication helps reduce pain perception, allowing individuals to experience pain relief.

How Does Vicodin Affect The Body?

Vicodin affects the body in various ways. Some of the most significant effects, beyond pain relief, include:

  • Euphoria and Relaxation. Hydrocodone stimulates the brain’s reward system, releasing dopamine — a neurotransmitter associated with pleasure and reward. This can lead to euphoria, relaxation, and a sense of well-being. Sadly, these effects contribute to the potential for misuse and addiction, as individuals may seek out the pleasurable sensations induced by the drug.
  • Central Nervous System Suppression. Opioids like hydrocodone slow down the central nervous system (CNS), leading to sedation and drowsiness. Even though this effect can be beneficial for pain management, it also poses risks because excessive CNS depression can lead to decreased alertness, impaired coordination, and difficulty performing tasks that require focus and attention.
  • Respiratory Depression. One of the most significant risks associated with opioid use, including Vicodin, is respiratory depression. Opioids can slow down the rate and depth of breathing, which can be life-threatening in overdose cases. This is why it’s crucial for individuals taking Vicodin to follow their prescribed dosage and not exceed it.
  • Gastrointestinal Effects. Opioids can also cause constipation by affecting the gastrointestinal tract muscles. This is a common side effect of Vicodin use and often requires additional medications to alleviate the discomfort.
  • Tolerance and Dependence. Prolonged use of Vicodin can lead to the development of tolerance, where the body becomes accustomed to the drug’s effects, requiring higher doses to achieve the same pain-relieving effects. Additionally, the body can become physically dependent on the drug, leading to withdrawal symptoms if the medication is abruptly discontinued.
  • Risk of Addiction. Opioids like hydrocodone have a significant potential for abuse and addiction. The pleasurable effects, combined with the development of tolerance and withdrawal symptoms, can lead individuals to misuse Vicodin. Addiction can have severe consequences on mental health, physical health, and overall well-being.
  • Cognitive Effects. Opioid use, especially in higher doses, can impair cognitive function. Individuals might experience difficulties with concentration, memory, and decision-making. These cognitive effects can impact daily functioning and contribute to mental health challenges.

It’s important to note that Vicodin should only be used as prescribed by a healthcare professional. Taking more than the prescribed dose, using it for non-medical purposes, or combining it with alcohol or other substances can increase risks and potentially adverse effects.

How Does Vicodin Affect Mental Health?

As more and more individuals receive prescription medication, there’s a growing concern about the potential link between opioid use, including Vicodin, and the increased risk of certain mental health disorders.

Opioids have a profound impact on the brain’s reward system, leading to feelings of euphoria and relaxation. However, these effects can also trigger an increased risk of mental health disorders. Research has shown a strong correlation between opioid misuse and mental health conditions, such as depression, anxiety, and substance use disorders.

Excessive use of Vicodin can specifically increase the risk of:

  • Depression. Using Vicodin, which contains opioids, can mess with the brain’s chemistry, making individuals feel down and affecting their mood. It can also mess up the brain’s systematic process for feeling good, leading to a lack of pleasure. Additionally, withdrawal symptoms from Vicodin can also make individuals feel low. If individuals are dealing with other problems like constant pain, trouble sleeping, or negative things, taking Vicodin could make them more likely to feel really sad and down.
  • Anxiety. Even though Vicodin contains an opioid, which is a sedative, it can still trigger anxiety. When consumed, opioids like Vicodin reduce the level of norepinephrine in the body, which controls alertness. When opioids are metabolized by the body and leave the system, they stop releasing norepinephrine. In response, the brain produces excessive norepinephrine to make up the difference, triggering anxiety, jitteriness, and muscle cramps.

Prevention and Responsible Use

Individuals prescribed Vicodin need to have an open and honest conversation with their healthcare provider about their mental health history and any concerns they may have. They can help tailor a pain management plan that minimizes the potential risks associated with opioids. Other ideas for Vicodin addiction prevention and excessive use include:

  • Monitoring and Awareness. Regularly assess mental and emotional well-being while taking Vicodin. If you notice any changes in mood, behavior, or thought patterns, consult your healthcare provider promptly. Early intervention can prevent the escalation of mental health issues.
  • Non-Opioid Alternatives. Depending on the nature and severity of pain, there might be alternative pain management strategies that are less likely to impact your mental health. Physical therapy, mindfulness techniques, and non-opioid pain relievers could be explored under the guidance of your healthcare provider.

Experts You Can Trust

Vicodin, like other opioids, presents a complex picture regarding mental health. While it undoubtedly relieves physical pain, its potential impact on mental health should not be overlooked. The risk of developing mental health disorders appears to be higher among those who misuse opioids, either intentionally or inadvertently. By promoting informed and responsible use, fostering open communication with healthcare providers, and considering alternative pain management strategies, individuals can minimize Vicodin’s potential risks and prioritize their physical and mental well-being. Contact us today to learn more.


Dr. Mohammed Saeed, MD.

Dr. Saeed is a psychiatry specialist with over 40 years of experience in the medical field. He received training in General Psychiatry at the University of Texas Medical Branch, where he was selected as the Medical Director of the Division of Child and Adolescent Psychiatry. He currently serves as the medical director at Into Action Recovery Centers. Full Bio

You Might Also Like: